Furman W R, Summer W R, Kennedy T P, Sylvester J T
Crit Care Med. 1982 Jun;10(6):371-4. doi: 10.1097/00003246-198206000-00007.
The relative vasodilating properties of isoproterenol, dopamine, and dobutomine on hypoxic pulmonary vasoconstriction were examined in isolated pig lungs, ventilated and perfused in situ. The flow-resistant properties of the pulmonary circulation were assessed by measuring the relationship between pulmonary arterial pressure (PAP) and flow (Q). Hypoxia ( a decrease in inspired O2 tension form 200 torr to 50 torr) caused a rightward shift and decreased in the slope of this relationship. This increase PAP an average of 18.8 torr when measured at a blood flow of 1 L/min. Isoproterenol and dobutamine inhibited hypoxic pulmonary vasoconstriction, whereas dopamine had no effect. Because of its relative freedom from adverse side-effects in clinical trials, dobutamine should be considered in patients with hypoxic pulmonary vasoconstriction and right heart failure.
在原位进行通气和灌注的离体猪肺中，研究了异丙肾上腺素、多巴胺和多巴酚丁胺对缺氧性肺血管收缩的相对血管舒张特性。通过测量肺动脉压（PAP）与血流量（Q）之间的关系来评估肺循环的血流阻力特性。缺氧（吸入氧分压从200托降至50托）导致这种关系向右移位且斜率降低。当在血流量为1升/分钟时进行测量，这使PAP平均升高18.8托。异丙肾上腺素和多巴酚丁胺抑制缺氧性肺血管收缩，而多巴胺则无作用。由于多巴酚丁胺在临床试验中相对无不良副作用，对于患有缺氧性肺血管收缩和右心衰竭的患者应考虑使用。
