一名患有鸟分枝杆菌复合群感染并伴有系统性红斑狼疮的患者。

A patient with a Mycobacterium avium complex infection complicated by systemic lupus erythematosus.

作者信息

Takada Kunio, Suzuki Kimihiro, Kataharada Koji, Okada Makoto, Nakashima Masahiro, Nakanishi Takashi, Ohsuzu Fumitaka, Yoshiyama Takashi

机构信息

First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan.

出版信息

J Infect Chemother. 2004 Feb;10(1):49-52. doi: 10.1007/s10156-003-0282-2.

DOI:10.1007/s10156-003-0282-2

PMID:14991519

Abstract

A 41-year-old woman was admitted to our hospital because of fever and polyarthralgia. A diagnosis of systemic lupus erythematosus (SLE) was made based on the findings of polyarthritis, leukocytopenia, lymphocytopenia, proteinuria, and positive reactions for antinuclear antibody (ANA) and anti-double strand (ds)DNA antibody. She had also been suffering from a pulmonary Mycobacterium avium complex (MAC) infection with such symptoms as cough and sputum for the past 3 years. Antimicrobial drugs for MAC infection were administered first, and later she was given cyclophosphamide pulse therapy, consisting of methylprednisolone (8 mg/day) and mizoribine (100 mg/day). Owing to these therapeutic regimens, SLE was successfully treated without an exacerbation of the MAC infection. The risk factors for MAC infection and SLE are also discussed.

摘要

一名41岁女性因发热和多关节痛入院。根据多关节炎、白细胞减少、淋巴细胞减少、蛋白尿以及抗核抗体（ANA）和抗双链（ds）DNA抗体阳性结果，诊断为系统性红斑狼疮（SLE）。在过去3年里，她还一直患有肺部鸟分枝杆菌复合群（MAC）感染，伴有咳嗽、咳痰等症状。首先给予治疗MAC感染的抗菌药物，之后给予她环磷酰胺冲击疗法，包括甲泼尼龙（8毫克/天）和咪唑立宾（100毫克/天）。由于这些治疗方案，SLE得到成功治疗，且MAC感染未加重。还讨论了MAC感染和SLE的危险因素。