Lindsey I, Jones O M, Cunningham C, Mortensen N J McC
Department of Colorectal Surgery, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU,
Br J Surg. 2004 Mar;91(3):270-9. doi: 10.1002/bjs.4531.
The treatment of chronic anal fissure has shifted in recent years from surgical to medical.
A Medline search of studies relevant to modern management of chronic anal fissure was undertaken.
Traditional surgery that permanently weakens the internal sphincter is associated with a risk of incontinence. Medical therapies temporarily relax the internal sphincter and pose no such danger, but their limited efficacy has led to displacement rather than replacement of traditional surgery. Emerging medical therapies promise continued improvement and new sphincter-sparing surgery may render traditional surgery redundant.
First-line use of medical therapy cures most chronic anal fissures cheaply and conveniently. The few non-responders can be targeted for sphincter assessment before traditional surgery. If the initial good results of new sphincter-sparing surgery are confirmed, it may be possible to avoid any risk of incontinence, while achieving high rates of fissure healing.
近年来,慢性肛裂的治疗已从手术治疗转向药物治疗。
对与慢性肛裂现代管理相关的研究进行了医学文献数据库检索。
永久性削弱内括约肌的传统手术存在失禁风险。药物治疗可暂时放松内括约肌,不存在此类风险,但其疗效有限,导致其地位发生变化,而非取代传统手术。新兴的药物治疗有望持续改进,新的保留括约肌手术可能使传统手术变得多余。
一线使用药物治疗可廉价、方便地治愈大多数慢性肛裂。少数无反应者可在传统手术前进行括约肌评估。如果新的保留括约肌手术的初步良好结果得到证实,那么在实现高肛裂愈合率的同时,有可能避免任何失禁风险。