用A型肉毒杆菌毒素治疗胃肠道括约肌痉挛。
Treatment of gastrointestinal sphincters spasms with botulinum toxin A.
作者信息
Brisinda Giuseppe, Sivestrini Nicola, Bianco Giuseppe, Maria Giorgio
机构信息
Department of Surgery, University Hospital "Agostino Gemelli", Largo Agostino Gemelli 8, 00168 Rome, Italy.
出版信息
Toxins (Basel). 2015 May 29;7(6):1882-916. doi: 10.3390/toxins7061882.
Abstract
Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.
摘要
A型肉毒杆菌毒素可抑制神经肌肉传递。它已成为一种具有多种适应证的药物。临床应用范围不断扩大，涵盖了多种神经和非神经疾病。该领域的最新成果之一是观察到A型肉毒杆菌毒素对胃肠道疾病有益。尽管毒素会阻断自主神经系统中的胆碱能神经末梢，但研究还表明它不会阻断由一氧化氮介导的非肾上腺素能非胆碱能反应。这进一步激发了人们将A型肉毒杆菌毒素用于治疗过度活跃的平滑肌和括约肌的兴趣。这种疗法的引入使几种临床疾病的治疗在门诊环境中变得更加容易，成本更低且无永久性并发症。本综述介绍了目前关于A型肉毒杆菌毒素用于治疗胃肠道病理状况的数据。
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