Rainesalo Sirpa, Keränen Tapani, Palmio Johanna, Peltola Jukka, Oja Simo S, Saransaari Pirjo
Brain Research Center, Medical School, University of Tampere, Finland.
Neurochem Res. 2004 Jan;29(1):319-24. doi: 10.1023/b:nere.0000010461.34920.0c.
Altered plasma and cerebrospinal fluid amino acid levels may be associated with human epilepsy. We studied three groups of patients, those with a generalized epileptic syndrome, juvenile myoclonic epilepsy, patients with refractory localization-related epilepsies, and patients with acute seizures (within 24 h). Plasma levels of amino acids were studied in all patient groups, as were those in the cerebrospinal fluid (CSF) of patients with acute seizures. After acute seizures, the amino acid changes in the CSF were limited to a reduction in the level of taurine, whereas the levels of most amino acids in plasma were decreased. On the other hand, levels of the excitatory amino acids glutamate and aspartate were increased. The most notable finding in the juvenile myoclonic epilepsy patients was an increase in glutamate level in the plasma. Our study supports the conception of an altered metabolism of glutamate in generalized epilepsies.
血浆和脑脊液氨基酸水平的改变可能与人类癫痫有关。我们研究了三组患者，分别是患有全身性癫痫综合征、青少年肌阵挛性癫痫的患者，难治性局灶性癫痫患者，以及急性发作（24小时内）的患者。对所有患者组的血浆氨基酸水平进行了研究，对急性发作患者的脑脊液（CSF）氨基酸水平也进行了研究。急性发作后，脑脊液中的氨基酸变化仅限于牛磺酸水平降低，而血浆中大多数氨基酸水平下降。另一方面，兴奋性氨基酸谷氨酸和天冬氨酸水平升高。青少年肌阵挛性癫痫患者最显著的发现是血浆中谷氨酸水平升高。我们的研究支持全身性癫痫中谷氨酸代谢改变的概念。
