肿瘤坏死因子α基因多态性与脑梗死相关。
Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction.
作者信息
Um Jae-Young, Kim Hyung-Min
机构信息
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoigi-Dong, Dongdaemun-Gu, Seoul 130-701, South Korea.
出版信息
Brain Res Mol Brain Res. 2004 Mar 17;122(1):99-102. doi: 10.1016/j.molbrainres.2003.11.019.
We examined whether promoter region polymorphism in the tumor necrosis factor-alpha (TNFalpha) gene at position -308 affects the odds of cerebral infarction (CI). We genotyped 366 CI patients and 610 healthy controls for the same polymorphism. A significant decrease was found for the TNFalpha A allele in CI patients compared with controls (P=0.003). Our finding suggests that TNFalpha promoter region polymorphism is responsible for susceptibility to CI in Koreans.
我们研究了肿瘤坏死因子-α（TNFα）基因-308位启动子区域多态性是否影响脑梗死（CI）的发病几率。我们对366例CI患者和610例健康对照进行了该多态性的基因分型。与对照组相比，CI患者中TNFα A等位基因显著减少（P = 0.003）。我们的研究结果表明，TNFα启动子区域多态性是韩国人易患CI的原因。
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