Salih Caner, Sheppard Mary N, Ho Siew Yen
Departments of Pediatrics and Histopathology, Imperial College, London, United Kingdom.
Ann Thorac Surg. 2004 Mar;77(3):903-7; discussion 907. doi: 10.1016/j.athoracsur.2003.07.046.
Hypoplastic left heart syndrome is a condition characterized by a constellation of morphological malformations affecting the left side of the heart. We studied the capillary network, and quantified the capillarization of the ventricular myocardium, which, if different from normal, may have implications for the success of surgical reconstruction.
The capillaries were detected by immunohistochemistry using a monoclonal antibody (von Willebrand's factor) against the endothelium. Hearts with hypoplastic left heart syndrome have higher mean and maximal diffusion distances from any arbitrary point to the nearest capillary than normal hearts.
There was no significant difference in the heterogeneity of capillary distribution between the hearts with hypoplastic left heart syndrome and the control heart. Increase in distance was found in both the right and left ventricles.
Hearts with hypoplastic left heart syndrome show a reduction in the capillarization of both the right and left ventricles compared with age-matched controls. We believe this may be an inherent abnormality of hypoplastic left heart syndrome that may have implications for ventricular development.
左心发育不全综合征是一种以影响心脏左侧的一系列形态畸形为特征的病症。我们研究了毛细血管网络，并对心室心肌的毛细血管化进行了量化，若其与正常情况不同，可能会对手术重建的成功产生影响。
使用针对内皮细胞的单克隆抗体（血管性血友病因子）通过免疫组织化学检测毛细血管。与正常心脏相比，左心发育不全综合征心脏从任意点到最近毛细血管的平均和最大扩散距离更高。
左心发育不全综合征心脏与对照心脏之间毛细血管分布的异质性无显著差异。在右心室和左心室均发现距离增加。
与年龄匹配的对照相比，左心发育不全综合征心脏的右心室和左心室毛细血管化均减少。我们认为这可能是左心发育不全综合征的一种固有异常，可能对心室发育产生影响。
