Putney J W
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences/NIH, PO Box 12233, Research Triangle Park, NC 27709, USA.
Mol Interv. 2001 Jun;1(2):84-94.
The versatility of Ca(2+) as a messenger in multiple signaling events requires that the concentration of calcium ions within the cytoplasm be highly regulated. In particular, the release of calcium from intracellular stores must often be linked to calcium influx across the cell membrane. Capacitative calcium entry, whereby the depletion of intracellular Ca(2+) stores induces the influx of extracellular calcium, is a crucial element of concerted calcium signaling. Investigations into the phenomenon are contributing to a new appreciation for the organized cytoplasmic framework that supports calcium signaling.
钙离子作为多种信号传导事件中的信使，其多功能性要求细胞质内钙离子的浓度受到高度调节。特别是，细胞内钙库释放的钙通常必须与跨细胞膜的钙内流相联系。容量性钙内流，即细胞内Ca(2+) 库的耗竭诱导细胞外钙内流，是协同钙信号传导的关键要素。对这一现象的研究有助于人们对支持钙信号传导的有组织的细胞质框架有新的认识。
