Lai J, Ossipov M H, Vanderah T W, Malan T P, Porreca F
Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724, USA.
Mol Interv. 2001 Aug;1(3):160-7.
One of the curious but common consequences of opioid administration in the clinical setting is the induction, at sites uninvolved in the original presentation of discomfort, of pain itself. The induction of pain is also a reliable, measurable phenomenon in animals receiving continuous delivery of opioid. Such pain induction is associated with the expression of spinal dynorphin, a finding that is especially intriguing in light of dynorphin's ability to recapitulate many of the characteristics of chronic, neuropathic pain when administered intrathecally (i.e., into the spine). The effective treatment of chronic pain syndromes-and of tolerance to antinociceptive therapies-may thus rest on an understanding of the biological roles of dynorphin in neurotransmission.
在临床环境中，使用阿片类药物会产生一种奇特但常见的后果，即在最初未出现不适的部位诱发疼痛本身。在持续接受阿片类药物的动物中，疼痛的诱发也是一种可靠的、可测量的现象。这种疼痛诱发与脊髓强啡肽的表达有关，鉴于强啡肽鞘内注射（即注入脊髓）时能够重现许多慢性神经性疼痛的特征，这一发现尤其引人关注。因此，慢性疼痛综合征以及对抗痛觉疗法耐受性的有效治疗可能取决于对强啡肽在神经传递中的生物学作用的理解。
