Edwards Dean P, Boonyaratanakornkit Viroj
Department of Pathology and Program in Molecular Biology, University of Colorado Health Sciences Center Denver, CO 80262, USA.
Mol Interv. 2003 Feb;3(1):12-5. doi: 10.1124/mi.3.1.12.
In addition to their well-studied ability to transactivate the expression of many genes, estrogen receptors (ERs) also effect cytoplasmic changes occurring too quickly to be accounted for by gene expression. Indeed, these immediate, "nongenomic" effects have been intensely studied, but the identification of important protein partners in quick ER-mediated signaling has lagged behind. Now, Wong et al. have identified MNAR (modulator of nongenomic activity of estrogen receptor) as an adaptor protein that allows the ER to bridge the signaling pathways of tyrosine kinases (i.e., Src) and the mitogen-activated protein kinase (MAPK) cascade. The MNAR-ER complex also appears to positively influence ER-mediated gene expression.
除了其激活许多基因表达的能力已得到充分研究外，雌激素受体（ERs）还会引发细胞质变化，其发生速度太快，无法用基因表达来解释。事实上，这些即时的“非基因组”效应已得到深入研究，但在快速的雌激素受体介导的信号传导中，重要蛋白质伴侣的鉴定却滞后了。现在，黄等人已将MNAR（雌激素受体非基因组活性调节剂）鉴定为一种衔接蛋白，它使雌激素受体能够连接酪氨酸激酶（即Src）和丝裂原活化蛋白激酶（MAPK）级联的信号通路。MNAR-雌激素受体复合物似乎也对雌激素受体介导的基因表达产生积极影响。
