He W X, Niu Z Y, Zhao S L, Chen J
School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China.
Shanghai Kou Qiang Yi Xue. 2001 Sep;10(3):246-8.
To investigate the expression of Smad 2 gene in human tooth germ,and the possible function of Smad 2 during human tooth germ development.
Immunohistochemical staining on prepared specimens of different stages of developing human tooth germ.
Smad 2 expression had specific temporal-spatial pattern during tooth germ development, which was similar to TGF-beta.
The expression of Smad 2 gene in tooth germ was detected in different stages of human tooth germ. The results suggest that Smad 2, one of the intracellular downstream molecules of TGF-beta, and as an inductive signal mediating epithelial-mesenchymal interaction, may regulate the differentiation of ameloblast and odontoblast cells, and modulate dentinogenesis and amelogenesis.
研究Smad 2基因在人牙胚中的表达情况，以及Smad 2在人牙胚发育过程中的可能作用。
对制备的人牙胚不同发育阶段的标本进行免疫组织化学染色。
Smad 2在牙胚发育过程中具有特定的时空表达模式，与转化生长因子-β（TGF-β）相似。
在人牙胚的不同阶段检测到了Smad 2基因的表达。结果表明，Smad 2作为TGF-β的细胞内下游分子之一，作为介导上皮-间充质相互作用的诱导信号，可能调节成釉细胞和成牙本质细胞的分化，并调节牙本质形成和釉质形成。
