Sharpe Juanita C, Arnoult Damien, Youle Richard J
Biochemistry Section, Surgical Neurology Branch, NINDS, NIH, Bethesda, MD 20892, USA.
Biochim Biophys Acta. 2004 Mar 1;1644(2-3):107-13. doi: 10.1016/j.bbamcr.2003.10.016.
Programmed cell death (apoptosis) is regulated by the Bcl-2 family of proteins. Although it remains unclear how these family members control apoptosis, they clearly have the capacity to regulate the permeability of intracellular membranes to ions and proteins. Proapoptotic members of the Bcl-2 family, especially Bax and Bid, have been extensively analyzed for the ability to form channels in membranes and to regulate preexisting channels. Anti-apoptotic members of the family tend to have the opposing effects on membrane channel formation. The molecular mechanisms of the different models for the permeabilization of membranes by the Bcl-2 family members and the regulation of Bcl-2 family member subcellular localizations are discussed.
程序性细胞死亡（凋亡）受Bcl-2蛋白家族调控。尽管目前尚不清楚这些家族成员如何控制凋亡，但它们显然具有调节细胞内膜对离子和蛋白质通透性的能力。Bcl-2家族的促凋亡成员，尤其是Bax和Bid，已被广泛分析其在膜中形成通道以及调节已有通道的能力。该家族的抗凋亡成员往往对膜通道形成具有相反的作用。本文讨论了Bcl-2家族成员使膜通透化的不同模型的分子机制以及Bcl-2家族成员亚细胞定位的调控。
