血管内降温作为直接经皮冠状动脉介入治疗辅助手段的可行性（低温试验研究结果）
Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study).
作者信息
Kandzari David E, Chu Alan, Brodie Bruce R, Stuckey Thomas A, Hermiller James B, Vetrovec George W, Hannan Karen L, Krucoff Mitchell W, Christenson Robert H, Gibbons Raymond J, Sigmon Kristina N, Garg Jyostna, Hasselblad Victor, Collins Kenneth, Harrington Robert A, Berger Peter B, Chronos Nicholas A, Hochman Judith S, Califf Robert M
机构信息
Duke Clinical Research Institute, Durham, North Carolina 27715, USA.
出版信息
Am J Cardiol. 2004 Mar 1;93(5):636-9. doi: 10.1016/j.amjcard.2003.11.038.
In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve creatinine kinase-MB and technetium-99m single-photon emission computed tomography sestamibi) and the quality of myocardial perfusion (continuous ST-segment monitoring). Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5 degrees C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.
在一项关于急性心肌梗死治疗性低温的非随机可行性研究中，18例患者接受血管内降温治疗（Alsius公司，加利福尼亚州欧文市），作为对直接经皮冠状动脉介入治疗的辅助治疗，以评估梗死面积的测量指标（肌酸激酶-MB曲线下面积和锝-99m单光子发射计算机断层扫描心肌灌注显像）以及心肌灌注质量（连续ST段监测）。围手术期血管内降温成功降低了核心体温（中位数33.5摄氏度），且耐受性良好，这支持在关键试验中评估辅助性低温治疗以限制梗死面积并减少再灌注损伤。
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