Flory Janine D, Manuck Stephen B, Perel James M, Muldoon Matthew F
Behavioral Physiology Laboratory 506 OEH, University of Pittsburgh, 4015 O'Hara Street, Pittsburgh, PA 15260, USA.
Psychopharmacology (Berl). 2004 Jul;174(3):376-80. doi: 10.1007/s00213-003-1763-9. Epub 2004 Mar 2.
Dimensional personality characteristics (e.g. impulsivity) and related behaviors and psychiatric disorders are linked to abnormalities of central nervous system (CNS) serotonergic functioning. Although neuroendocrine [e.g. plasma prolactin (PRL)] responses to the serotonin agonist, fenfluramine, have been used widely to index CNS serotonergic responsivity, safety concerns constrain continued use of fenfluramine. Citalopram, which inhibits serotonin reuptake, may serve as an alternative pre-synaptic neuropharmacologic challenge agent, due to its high selectivity and absence of intrinsic activity at serotonin or other receptor families. Twenty-two healthy adults who had been administered a fenfluramine challenge before May 1996 completed a 5-h oral citalopram challenge 3-6 years later. PRL responsivity to citalopram correlated significantly with PRL response to fenfluramine for baseline-corrected maximal and area-under-the-curve (AUC) indices ( r's > or =0.49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity.
维度人格特征（如冲动性）以及相关行为和精神障碍与中枢神经系统（CNS）血清素能功能异常有关。尽管神经内分泌反应（如血浆催乳素[PRL]）对血清素激动剂芬氟拉明的反应已被广泛用于衡量中枢神经系统血清素能反应性，但由于安全问题，芬氟拉明的持续使用受到限制。西酞普兰可抑制血清素再摄取，因其高选择性以及对血清素或其他受体家族无内在活性，可能作为一种替代性的突触前神经药理学激发剂。22名在1996年5月前接受过芬氟拉明激发试验的健康成年人，在3至6年后完成了一次为期5小时的口服西酞普兰激发试验。对于基线校正后的最大指数和曲线下面积（AUC）指数，PRL对西酞普兰的反应性与PRL对芬氟拉明的反应显著相关（相关系数r≥0.49，P≤0.02）。考虑到两次激发试验之间的时间间隔，这种相关性的程度值得注意。结果支持使用西酞普兰作为一种替代性神经内分泌激发试验来衡量中枢神经系统血清素能反应性
