大鼠肝脏中的免疫球蛋白重链结合蛋白/葡萄糖调节蛋白78（BiP/GRP78）会被一种过氧化物酶体增殖剂氯贝丁酯下调。
Rat liver BiP/GRP78 is down-regulated by a peroxisome-proliferator, clofibrate.
作者信息
Motojima K, Goto S
机构信息
Department of Biochemistry, School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
出版信息
FEBS Lett. 1992 Aug 17;308(2):207-10. doi: 10.1016/0014-5793(92)81275-q.
PMID:1499732
Abstract
Administration of clofibrate in rat results in down-regulation of several liver proteins and a vast induction of peroxisomal proteins. One protein was identified as BiP/GRP78 using antibodies and cDNA cloning. The level of mRNA was reduced by the drug.
摘要
在大鼠中给予氯贝丁酯会导致几种肝脏蛋白表达下调，并大量诱导过氧化物酶体蛋白。使用抗体和cDNA克隆鉴定出一种蛋白为BiP/GRP78。该药物使mRNA水平降低。
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