血清肌酸激酶在异位骨化早期诊断中的价值。
The value of serum creatine kinase in early diagnosis of heterotopic ossification.
作者信息
Sherman Andrew L, Williams Joan, Patrick Lornette, Banovac Kresimir
机构信息
University of Miami School of Medicine, Department of Rehabilitation Medicine, Miami, Florida, USA.
出版信息
J Spinal Cord Med. 2003 Fall;26(3):227-30. doi: 10.1080/10790268.2003.11753688.
BACKGROUND
Heterotopic ossification (HO) is a complication of spinal cord injury (SCI) characterized by formation of ectopic bone. Early diagnosis is critical, but available diagnostic methods have drawbacks. Serum creatine kinase may be a marker for the development and severity of HO.
PARTICIPANTS
18 SCI patients with diagnosed HO based on clinical findings and bone scintigraphy.
METHODS
Serum creatine kinase levels were taken at the time of diagnosis of HO and during subsequent etidronate therapy.
RESULTS
Of the 14 patients with normal creatine kinase values, 13 had no evidence of HO on follow-up radiographic examination. Of the 4 patients with elevated creatine kinase, all developed radiographic signs of HO.
CONCLUSION
Elevated serum creatine kinase may be associated with a more aggressive course of HO as well as resistance to etidronate therapy. Further studies are needed to determine whether creatine kinase may serve as a marker for early, active HO.
背景
异位骨化（HO）是脊髓损伤（SCI）的一种并发症，其特征为异位骨的形成。早期诊断至关重要，但现有的诊断方法存在缺陷。血清肌酸激酶可能是HO发生和严重程度的一个标志物。
参与者
18例基于临床检查结果和骨闪烁显像诊断为HO的SCI患者。
方法
在诊断HO时以及随后的依替膦酸治疗期间测定血清肌酸激酶水平。
结果
在14例肌酸激酶值正常的患者中，13例在后续的影像学检查中没有HO的证据。在4例肌酸激酶升高的患者中，所有患者均出现了HO的影像学征象。
结论
血清肌酸激酶升高可能与HO更具侵袭性的病程以及对依替膦酸治疗的抵抗有关。需要进一步研究以确定肌酸激酶是否可作为早期、活跃HO的标志物。
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