接受哌拉西林-他唑巴坦治疗的患者半乳甘露聚糖Platelia曲霉试验结果出现假阳性。
False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam.
作者信息
Viscoli Claudio, Machetti Marco, Cappellano Paola, Bucci Barbara, Bruzzi Paolo, Van Lint Maria Teresa, Bacigalupo Andrea
机构信息
Infectious Disease Unit, National Institute for Cancer Research and University of Genoa, Genoa, Italy.
出版信息
Clin Infect Dis. 2004 Mar 15;38(6):913-6. doi: 10.1086/382224. Epub 2004 Feb 27.
At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P<.001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.
在圣马蒂诺医院（热那亚）的骨髓移植中心，我们观察到Platelia曲霉菌（PA；伯乐公司）检测结果呈阳性的患者比例有所上升，从1999年1月至2003年1月期间的10%（386例患者中的38例）增至2003年2月至2003年5月期间的36%（59例患者中的21例）。阳性结果与哌拉西林-他唑巴坦（PT）的使用显著相关（P<0.001）（接受PT治疗的23例患者中有17例[74%]检测结果呈阳性，而未接受PT治疗的36例患者中有4例[11%]呈阳性）。多变量分析发现，PT的使用（χ2=34.7；P<0.001）和基础疾病（χ2=21.14；P<0.001）与PA阳性相关。在检测的15批PT中，有12批PA检测结果呈阳性。
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