Pérez-Martínez C, Durán-Navarrete A J, García-Fernández R A, Espinosa-Alvarez J, Escudero Diez A, García-Iglesias M J
Histology and Pathological Anatomy Section, Department of Animal Pathology: Animal Medicine, Faculty of Veterinary Science, University of León, 24071 León, Spain.
J Comp Pathol. 2004 Feb-Apr;130(2-3):117-23. doi: 10.1016/j.jcpa.2003.09.007.
Of 1489 slaughtered cattle, 11 had ovarian granulosa cell tumours (GCTs). These GCTs were examined immunohistochemically for proliferating cell nuclear antigen (PCNA) and oestrogen receptor (ER) in relation to histopathological features (growth pattern, nuclear atypia and mitotic count). On the basis of nuclear atypia and mitotic count, the prognosis for GCTs with a diffuse growth pattern appeared less favourable than that for GCTs with a follicular or trabecular pattern. Increased PCNA expression was significantly associated with nuclear atypia but not with histological growth pattern or mitotic count. A novel finding was the presence of ERbeta but not ERalpha in bovine ovarian GCTs. However, ERbeta expression did not appear to be related to the histopathological features examined. The results indicate that PCNA expression may be of value in establishing the biological behaviour of bovine GCTs. However, a larger series of bovine GCTs should be examinated to assess the prognostic significance of ERbeta.
在1489头屠宰牛中，有11头患有卵巢颗粒细胞瘤（GCT）。对这些GCT进行免疫组织化学检查，以检测增殖细胞核抗原（PCNA）和雌激素受体（ER）与组织病理学特征（生长模式、核异型性和有丝分裂计数）的关系。基于核异型性和有丝分裂计数，弥漫性生长模式的GCT预后似乎比滤泡性或小梁状模式的GCT更差。PCNA表达增加与核异型性显著相关，但与组织学生长模式或有丝分裂计数无关。一个新发现是牛卵巢GCT中存在ERβ而非ERα。然而，ERβ表达似乎与所检查的组织病理学特征无关。结果表明，PCNA表达可能对确定牛GCT的生物学行为有价值。然而，应该检查更多系列的牛GCT以评估ERβ的预后意义。
