Cdc42：新的探索之路。

Cdc42: new roads to travel.

作者信息

Cerione Richard A

机构信息

Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.

出版信息

Trends Cell Biol. 2004 Mar;14(3):127-32. doi: 10.1016/j.tcb.2004.01.008.

DOI:10.1016/j.tcb.2004.01.008

PMID:15003621

Abstract

The roles of Cdc42 in stimulating changes in the actin cytoskeleton and in the establishment of cell polarity have been known for some time. However, evidence implicating Cdc42 in intracellular trafficking and in the regulation of cell growth have continued to surface. Recently, exciting developments have highlighted how Cdc42 might participate in these cellular functions by regulating the processing of the EGF receptor. Here, I discuss these findings within the broader context of how Cdc42 serves as a multifaceted signaling switch that links trafficking events to the control of cell growth.

摘要

一段时间以来，人们已经知道Cdc42在刺激肌动蛋白细胞骨架变化以及建立细胞极性方面所起的作用。然而，有证据表明Cdc42参与细胞内运输和细胞生长调控，且此类证据不断涌现。最近，令人兴奋的进展突出了Cdc42可能如何通过调节表皮生长因子（EGF）受体的加工过程来参与这些细胞功能。在此，我将在更广泛的背景下讨论这些发现，即Cdc42如何作为一个多方面的信号开关，将运输事件与细胞生长控制联系起来。