Vik-Mo Harald
Hjertemedisinsk avdeling, St. Olavs Hospital, 7006 Trondheim.
Tidsskr Nor Laegeforen. 2004 Mar 4;124(5):648-51.
Early and complete opening of the thrombotic occluded coronary artery is the best treatment of acute myocardial infarction with ST-segment elevation in ECG. Mechanical reperfusion with coronary angioplasty and pharmacological opening with fibrinolytic drugs are alternative therapies. Primary coronary angioplasty is the best therapy in hospitals with the necessary facilities, giving lower mortality, less reinfarction and stroke. Patients with transport time of less than 90 minutes should be treated with angioplasty. Patients in need of longer transport should have fibrinolytic therapy in their local hospital. The patient should be given analgesics and acetylsalicylic acid before transport to hospital. The value of prehospital fibrinolytic therapy and the use of glucoprotein IIb/IIIa receptor inhibitors before transport are disputed. After failed fibrinolytic treatment, rescue angioplasty can be done with good outcomes.
早期完全开通血栓闭塞的冠状动脉是心电图ST段抬高型急性心肌梗死的最佳治疗方法。冠状动脉血管成形术的机械再灌注和纤维蛋白溶解药物的药物开通是替代疗法。在具备必要设施的医院,直接冠状动脉血管成形术是最佳治疗方法,其死亡率更低,再梗死和中风发生率更低。转运时间少于90分钟的患者应接受血管成形术治疗。需要更长转运时间的患者应在当地医院接受纤维蛋白溶解治疗。患者在转运至医院前应给予镇痛药和阿司匹林。院前纤维蛋白溶解治疗的价值以及转运前使用糖蛋白IIb/IIIa受体抑制剂存在争议。纤维蛋白溶解治疗失败后,可行补救性血管成形术,效果良好。