子宫珠蛋白可逆转血小板活化因子（PAF）介导的自分泌环在HEC-1A细胞中的作用。 - Suppr

The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin.

作者信息

Peri Alessandro, Bonaccorsi Lorella, Cioppi Federica, Muratori Monica, Luconi Michaela, Granchi Simone, Maggi Mario, Baldi Elisabetta

机构信息

Department of Clinical Physiopathology, Endocrine Unit, University of Florence, Italy.

出版信息

Hum Cell. 2003 Sep;16(3):95-9. doi: 10.1111/j.1749-0774.2003.tb00139.x.

DOI:10.1111/j.1749-0774.2003.tb00139.x

PMID:15005239

Abstract

摘要

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The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin.子宫珠蛋白可逆转血小板活化因子（PAF）介导的自分泌环在HEC-1A细胞中的作用。

Hum Cell. 2003 Sep;16(3):95-9. doi: 10.1111/j.1749-0774.2003.tb00139.x.

Uteroglobin reverts the transformed phenotype in the endometrial adenocarcinoma cell line HEC-1A by disrupting the metabolic pathways generating platelet-activating factor.子宫珠蛋白通过破坏生成血小板活化因子的代谢途径，使子宫内膜腺癌细胞系HEC-1A的转化表型发生逆转。

Int J Cancer. 2000 Nov 15;88(4):525-34. doi: 10.1002/1097-0215(20001115)88:4<525::aid-ijc3>3.0.co;2-z.

Platelet-activating factor mediates an autocrine proliferative loop in the endometrial adenocarcinoma cell line HEC-1A.血小板活化因子介导子宫内膜腺癌细胞系HEC-1A中的自分泌增殖环。

Cancer Res. 1994 Sep 1;54(17):4777-84.

Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells.蛋白酪氨酸激酶、丝裂原活化蛋白激酶和蛋白激酶C参与血小板活化因子（PAF）在人子宫内膜癌细胞系HEC-1A中的促有丝分裂信号传导。

Biochim Biophys Acta. 1997 Feb 4;1355(2):155-66. doi: 10.1016/s0167-4889(96)00125-5.

Platelet-activating factor enhances production of insulin-like growth factor binding proteins in a human adenocarcinoma cell line (HEC-1A).血小板活化因子可增强人腺癌细胞系（HEC-1A）中胰岛素样生长因子结合蛋白的产生。

Gynecol Oncol. 1996 Jun;61(3):333-40. doi: 10.1006/gyno.1996.0152.

Platelet-activating factor in human endometrium.人子宫内膜中的血小板活化因子。

J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):359-63. doi: 10.1016/0960-0760(94)90280-1.

Mitogen-activated protein kinase activation and regulation of cyclooxygenase 2 expression by platelet-activating factor and hCG in human endometrial adenocarcinoma cell line HEC-1B.

J Reprod Fertil. 1999 Sep;117(1):49-59. doi: 10.1530/jrf.0.1170049.

Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation.雌激素通过一条涉及血小板活化因子介导的核因子-κB激活的途径增强血管生成。

Cancer Res. 2004 Sep 15;64(18):6482-8. doi: 10.1158/0008-5472.CAN-03-2774.

Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line.血小板活化因子（PAF）受体的激活通过蛋白激酶C-α刺激人子宫内膜上皮细胞系HEC-1B释放一氧化氮（NO）。

Mol Med. 2000 Jan;6(1):37-49.

Transforming growth factor-alpha and insulin-like growth factor-I, but not epidermal growth factor, elicit autocrine stimulation of mitogenesis in endometrial cancer cell lines.转化生长因子-α和胰岛素样生长因子-I而非表皮生长因子，可引发子宫内膜癌细胞系中促有丝分裂的自分泌刺激。

Gynecol Oncol. 1998 Aug;70(2):202-9. doi: 10.1006/gyno.1998.5089.

引用本文的文献

Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice.血小板激活因子阻断抑制 T 辅助细胞 17 型通路并抑制 K5.hTGF-β1 转基因小鼠的银屑病样皮肤疾病。

Am J Pathol. 2011 Feb;178(2):699-708. doi: 10.1016/j.ajpath.2010.10.008.

本文引用的文献

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation.环磷酸腺苷（cAMP）与丝裂原活化蛋白激酶（MAP激酶）信号通路在细胞增殖调控中的相互作用。

Trends Cell Biol. 2002 Jun;12(6):258-66. doi: 10.1016/s0962-8924(02)02294-8.

Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesis.血小板活化因子诱导的血管生成对核因子κB的依赖性

Cancer Res. 2002 Mar 15;62(6):1809-14.

Int J Cancer. 2000 Nov 15;88(4):525-34. doi: 10.1002/1097-0215(20001115)88:4<525::aid-ijc3>3.0.co;2-z.

Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene.通过子宫珠蛋白基因的过表达使癌细胞中转化表型丧失。

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3963-8. doi: 10.1073/pnas.96.7.3963.

Loss of uteroglobin expression in prostate cancer: relationship to advancing grade.前列腺癌中子宫珠蛋白表达缺失：与肿瘤分级进展的关系。

Clin Cancer Res. 1997 Dec;3(12 Pt 1):2295-300.

Biosynthesis of platelet-activating factor and enzyme inhibitors.血小板激活因子的生物合成及酶抑制剂

Adv Exp Med Biol. 1996;416:5-10. doi: 10.1007/978-1-4899-0179-8_2.

Biochim Biophys Acta. 1997 Feb 4;1355(2):155-66. doi: 10.1016/s0167-4889(96)00125-5.

Gynecol Oncol. 1996 Jun;61(3):333-40. doi: 10.1006/gyno.1996.0152.

Transfected platelet-activating factor receptor activates mitogen-activated protein (MAP) kinase and MAP kinase kinase in Chinese hamster ovary cells.转染的血小板活化因子受体激活中国仓鼠卵巢细胞中的丝裂原活化蛋白（MAP）激酶和MAP激酶激酶。

J Biol Chem. 1994 Jan 21;269(3):2307-15.

Platelet-activating factor in human endometrium.人子宫内膜中的血小板活化因子。

J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):359-63. doi: 10.1016/0960-0760(94)90280-1.

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The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin.

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