Soine W H, Duncan W, Lambert R, Middleberg R, Finley H, O'Neil D J
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond.
J Forensic Sci. 1992 Mar;37(2):513-27.
Common analytical methods used for identifying samples obtained from clandestine laboratories were evaluated for their ability to differentiate between possible amphetamine isomers and homologs. A series of ring-substituted (4-methyl, 4-methoxy, and 3,4-methylenedioxy) amphetamine and N-methylphenethylamine isomers was analyzed using color tests, thin-layer chromatography, gas chromatography/mass spectrometry (GC/MS) and GC/infrared (GC/IR). The N-acetyl derivatives of the isomers were analyzed using GC/IR/MS. GC/IR/MS readily differentiated the 4-methylphenylalkylamine isomers. MS and IR spectra were also obtained for each pair of the 4-methoxyphenylalkylamine isomers and the 3,4-methylenedioxyphenylalkylamine isomers, but differentiation via GC/IR/MS was difficult. The N-acetyl derivatives of each pair of isomers could be readily differentiated using GC/IR/MS. Good library researchable spectra for N-acetylamphetamine could be obtained for IR identification with 10 ng (on-column) and MS identification with 2 ng. The spectrometrically independent IR and MS data obtained for the N-acetyl derivatives indicated that the combination of GC/IR/MS can add a significant level of confidence in the analysis of ring-substituted arylalkylamines.
对用于鉴定从秘密实验室获取的样本的常用分析方法进行了评估，以确定其区分可能的苯丙胺异构体和同系物的能力。使用颜色测试、薄层色谱法、气相色谱/质谱联用仪（GC/MS）和气相色谱/红外光谱联用仪（GC/IR）对一系列环取代（4-甲基、4-甲氧基和3,4-亚甲基二氧基）苯丙胺和N-甲基苯乙胺异构体进行了分析。使用GC/IR/MS对异构体的N-乙酰基衍生物进行了分析。GC/IR/MS能够轻松区分4-甲基苯基烷基胺异构体。还获得了每对4-甲氧基苯基烷基胺异构体和3,4-亚甲基二氧基苯基烷基胺异构体的质谱和红外光谱，但通过GC/IR/MS进行区分很困难。使用GC/IR/MS可以轻松区分每对异构体的N-乙酰基衍生物。对于N-乙酰基苯丙胺，可以获得良好的可用于库检索的光谱，用于10 ng（柱上）的红外鉴定和2 ng的质谱鉴定。从N-乙酰基衍生物获得的光谱独立的红外和质谱数据表明，GC/IR/MS的组合可以在环取代芳基烷基胺的分析中增加显著的置信度。
