西伯利亚原住民恩加纳桑族和凯特族中HLA II类基因的变异情况。

Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations.

作者信息

Uinuk-Ool T S, Takezaki N, Derbeneva O A, Volodko N V, Sukernik R I

机构信息

Department of Immunogenetics, Max Planck Institute of Biology, Tübingen, Germany.

出版信息

Eur J Immunogenet. 2004 Feb;31(1):43-51. doi: 10.1111/j.1365-2370.2004.00443.x.

DOI:10.1111/j.1365-2370.2004.00443.x

PMID:15009181

Abstract

Allelic frequencies at the three most polymorphic loci of the HLA class II region (DRB1, DQA1 and DQB1) were determined in the Nganasan and Ket, the remnants of the two most ancient groups in the Lower Yenisey River/Taimyr Peninsula region in northern Siberia. By single-stranded conformational polymorphism typing, verified by sequencing, 19 HLA-DRB1-DQA1-DQB1 haplotypes and 15 HLA-DRB1, seven DQA1 and 11 DQB1 alleles were found. The most frequent alleles were DRB11301 (23.5%), DQA10103 (29.4%), 0501/03/05 (29.4%), and DQB10301/09 (32.4%) in the Ket, and DRB10901 (25%), DQA10301 (39.6%), and DQB1*0301/09 (37.5%) in the Nganasan. The distribution patterns and comprehensive phylogenic analysis based on the haplotype frequencies of 17 Siberian populations suggest that the founders of both the Ket and the Nganasan came from Palaeolithic populations in the Altai-Sayan Upland.

摘要

在西伯利亚北部叶尼塞河下游/泰梅尔半岛地区最古老的两个群体的后裔恩加纳桑人和凯特人中，确定了HLA II类区域三个多态性最高位点（DRB1、DQA1和DQB1）的等位基因频率。通过单链构象多态性分型并经测序验证，发现了19种HLA-DRB1-DQA1-DQB1单倍型以及15种HLA-DRB1、7种DQA1和11种DQB1等位基因。凯特人中最常见的等位基因是DRB11301（23.5%）、DQA10103（29.4%）、0501/03/05（29.4%）以及DQB10301/09（32.4%）；恩加纳桑人中最常见的等位基因是DRB10901（25%）、DQA10301（39.6%）以及DQB1*0301/09（37.5%）。基于17个西伯利亚人群单倍型频率的分布模式和综合系统发育分析表明，凯特人和恩加纳桑人的祖先均来自阿尔泰山-萨彦高地的旧石器时代人群。