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取代的2-巯基-3-(N-芳基)嘧啶并[5,4-c]喹喔啉-4-(3H)-酮的合成、抗菌及抗炎活性

Synthesis and antimicrobial and anti-inflammatory activities of substituted 2-mercapto-3-(N-aryl)pyrimido[5,4-c]cinnolin-4-(3H)-ones.

作者信息

Nargund L V, Badiger V V, Yarnal S M

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, J. N. Medical College, Belgaum, India.

出版信息

J Pharm Sci. 1992 Apr;81(4):365-6. doi: 10.1002/jps.2600810416.

DOI:10.1002/jps.2600810416
PMID:1501075
Abstract

Ten new substituted 2-mercapto-3-(N-aryl)pyrimido[5,4-c]cinnolin-4- (3H)-ones (4) were prepared by refluxing substituted 4-aminocinnolin-3-carboxylic acid (3) with substituted arylisothiocyanate in anhydrous pyridine. These derivatives were evaluated for their antimicrobial and anti-inflammatory activities. Some of the title compounds possess potent antimicrobial activity.

摘要

通过在无水吡啶中使取代的4-氨基喹喔啉-3-羧酸（3）与取代的芳基异硫氰酸酯回流反应，制备了10种新的取代的2-巯基-3-（N-芳基）嘧啶并[5,4-c]喹喔啉-4-（3H）-酮（4）。对这些衍生物的抗菌和抗炎活性进行了评估。一些标题化合物具有强效抗菌活性。

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