活体肝移植后丙型肝炎病毒所致胆汁淤积性肝炎

Cholestatic hepatitis due to hepatitis C virus after a living donor liver transplantation.

作者信息

Kaneko Junichi, Sugawara Yasuhiko, Akamatsu Nobuhisa, Kokudo Norihiro, Makuuchi Masatoshi

机构信息

Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Japan.

出版信息

Hepatogastroenterology. 2004 Jan-Feb;51(55):243-4.

PMID:15011874

Abstract

Recurrence of hepatitis C virus after liver transplantation is common and cholestatic hepatitis occurs in approximately 10% of the patients and leads to accelerated graft failure and death. A 47-year-old man underwent living donor liver transplantation for hepatitis C-related liver cirrhosis. Preemptive antiviral therapy was started using interferon-alpha2b (6 MU x 3 per week) and ribavirin (600 mg per day) two months after living donor liver transplantation. The response to the combined therapy was not satisfactory. He developed liver failure and expired 11 months after the transplantation. The present results indicate that a rapid development of graft failure can occur in spite of preemptive antiviral therapy after living donor liver transplantation.

摘要

肝移植后丙型肝炎病毒复发很常见，约10%的患者会发生胆汁淤积性肝炎，进而导致移植肝加速衰竭和死亡。一名47岁男性因丙型肝炎相关肝硬化接受了活体供肝肝移植。活体供肝肝移植术后两个月开始使用α-干扰素2b（每周3次，每次6 MU）和利巴韦林（每日600 mg）进行抢先抗病毒治疗。联合治疗的效果并不理想。他发生了肝衰竭，并在移植后11个月死亡。目前的结果表明，尽管活体供肝肝移植术后进行了抢先抗病毒治疗，但仍可能迅速发生移植肝衰竭。