Ye Sung-Joon, Brezovich Ivan A, Pareek Prem, Naqvi Shahid A
Department of Radiation Oncology, University of Alabama School of Medicine, 1824 6th Avenue South, Birmingham, AL 35294, USA.
Phys Med Biol. 2004 Feb 7;49(3):387-97. doi: 10.1088/0031-9155/49/3/003.
The expanding clinical use of low-energy photon emitting 125I and 103Pd seeds in recent years has led to renewed interest in their dosimetric properties. Numerous papers pointed out that higher accuracy could be obtained in Monte Carlo simulations by utilizing newer libraries for the low-energy photon cross-sections, such as XCOM and EPDL97. The recently developed PENELOPE 2001 Monte Carlo code is user friendly and incorporates photon cross-section data from the EPDL97. The code has been verified for clinical dosimetry of high-energy electron and photon beams, but has not yet been tested at low energies. In the present work, we have benchmarked the PENELOPE code for 10-150 keV photons. We computed radial dose distributions from 0 to 10 cm in water at photon energies of 10-150 keV using both PENELOPE and MCNP4C with either DLC-146 or DLC-200 cross-section libraries, assuming a point source located at the centre of a 30 cm diameter and 20 cm length cylinder. Throughout the energy range of simulated photons (except for 10 keV), PENELOPE agreed within statistical uncertainties (at worst +/- 5%) with MCNP/DLC-146 in the entire region of 1-10 cm and with published EGS4 data up to 5 cm. The dose at 1 cm (or dose rate constant) of PENELOPE agreed with MCNP/DLC-146 and EGS4 data within approximately +/- 2% in the range of 20-150 keV, while MCNP/DLC-200 produced values up to 9% lower in the range of 20-100 keV than PENELOPE or the other codes. However, the differences among the four datasets became negligible above 100 keV.
近年来,低能光子发射型125I和103Pd籽源在临床上的应用不断扩大,这使得人们对它们的剂量学特性重新产生了兴趣。许多论文指出,通过使用更新的低能光子截面库,如XCOM和EPDL97,在蒙特卡罗模拟中可以获得更高的精度。最近开发的PENELOPE 2001蒙特卡罗代码对用户很友好,并纳入了来自EPDL97的光子截面数据。该代码已针对高能电子束和光子束的临床剂量学进行了验证,但尚未在低能情况下进行测试。在本研究中,我们对PENELOPE代码在10 - 150 keV光子能量下进行了基准测试。我们假设一个点源位于直径30 cm、长度20 cm的圆柱体中心,使用PENELOPE和MCNP4C以及DLC - 146或DLC - 200截面库,计算了10 - 150 keV光子能量下水中从0到10 cm的径向剂量分布。在整个模拟光子能量范围内(10 keV除外),PENELOPE在1 - 10 cm的整个区域内与MCNP/DLC - 146在统计不确定度范围内(最差为±5%)一致,并且在5 cm范围内与已发表的EGS4数据一致。在20 - 150 keV范围内,PENELOPE在1 cm处的剂量(或剂量率常数)与MCNP/DLC - 146和EGS4数据的一致性约为±2%,而在20 - 100 keV范围内,MCNP/DLC - 200产生的值比PENELOPE或其他代码低达9%。然而,在100 keV以上,这四个数据集之间的差异可以忽略不计。