Kochhar Rakesh, Sethy Pradeepta Kumar, Nagi Birender, Wig Jay Dev
Clinical section, Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Gastroenterol Hepatol. 2004 Apr;19(4):418-22. doi: 10.1111/j.1440-1746.2003.03283.x.
Endoscopic balloon dilatation (EBD) has been used for the treatment of gastric outlet obstruction (GOO). There are several reports on the utility and success of this non-surgical treatment option in peptic GOO, with variable results. However, there are only a few reports documenting the efficacy of this method for non-peptic GOO. The authors here report on experience with balloon dilatation in peptic and non-peptic GOO over a 3-year period.
Twenty-three patients with benign GOO underwent EBD. Dilatation was carried out with through-the-scope balloon dilators after premedication. Dilatation was repeated every week and the response was documented on the basis of symptoms and endoscopic findings and barium studies. Helicobacter pylori was eradicated in patients with peptic GOO, when present.
The 23 patients with GOO included 11 with peptic ulcer as the etiology, eight with corrosive-induced and four with chronic pancreatitis (alcohol three, idiopathic one). Patients with peptic GOO required 1-3 sessions (mean 2.0 +/- 0.63) to achieve a diameter of 15 mm dilatation, with uniformly good response over a mean follow-up period of 14.04 +/- 9.79 months. Corrosive-induced GOO required a larger number of dilatation sessions (2-9, mean 5.63 +/- 2.88), but the response was equally good, with follow up of 12-30 months. Patients with pancreatitis-related GOO, however, failed to respond despite a mean of 5.50 (+/-0.58) dilatations, and continued to have symptoms. All these patients were subjected to surgical bypass. There were no major complications such as perforation.
A good response can be expected in the majority of patients with peptic and corrosive-related GOO after balloon dilatation; however, poor results are noted for chronic pancreatitis-related GOO.
内镜下球囊扩张术(EBD)已用于治疗胃出口梗阻(GOO)。关于这种非手术治疗方法在消化性GOO中的效用和成功率已有多篇报道,但结果各异。然而,仅有少数报道记录了该方法对非消化性GOO的疗效。本文作者报告了3年间在消化性和非消化性GOO中进行球囊扩张术的经验。
23例良性GOO患者接受了EBD。术前用药后,使用经内镜球囊扩张器进行扩张。每周重复扩张,并根据症状、内镜检查结果和钡剂造影记录反应。对于存在幽门螺杆菌感染的消化性GOO患者,进行幽门螺杆菌根除治疗。
23例GOO患者中,病因包括11例消化性溃疡、8例腐蚀性损伤和4例慢性胰腺炎(酒精性3例,特发性1例)。消化性GOO患者达到15mm扩张直径需要1 - 3次(平均2.0±0.63次)扩张,在平均14.04±9.79个月的随访期内反应均良好。腐蚀性损伤导致的GOO需要更多次数的扩张(2 - 9次,平均5.63±2.88次),但反应同样良好,随访时间为12 - 30个月。然而,胰腺炎相关的GOO患者尽管平均进行了5.50(±0.58)次扩张仍无反应,症状持续存在。所有这些患者均接受了手术旁路治疗。未出现穿孔等严重并发症。
大多数消化性和腐蚀性相关GOO患者球囊扩张术后可获得良好反应;然而,慢性胰腺炎相关GOO的效果不佳。