Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Sector 12, Chandigarh, 160012, India.
Surg Endosc. 2011 May;25(5):1579-84. doi: 10.1007/s00464-010-1442-y. Epub 2010 Oct 29.
Benign gastric outlet obstruction (GOO) causes considerable morbidity and conventional treatment has been surgery. Endoscopic balloon dilatation is a minimally invasive treatment modality for GOO but experience with its use is mainly in patients with GOO due to peptic ulcer disease. We report our experience of endoscopic balloon dilatation in benign GOO of various etiologies.
Over 4 years, 25 patients with benign GOO were treated by endoscopic balloon dilatation done with through-the-scope controlled radial expansion (CRE) balloon dilators. Dilatation was repeated every 2 weeks with the end point being dilation of 15 mm or the need for surgery. Helicobacter pylori, when present, was eradicated.
Etiology of benign GOO was peptic ulcer (11), corrosive ingestion (7), chronic pancreatitis (4, groove pancreatitis in 1), tuberculosis (2), and Crohn's disease (1). Endoscopic balloon dilatation was successful in 21/25 (84%) patients. Patients required one to six sessions of endoscopic dilatation (mean=2.2±1.2). Corrosive-induced GOO required more dilatation sessions (3.83±0.75) compared to peptic GOO (2.1±0.56; p<0.05). Balloon dilatation was also effective in patients with GOO due to gastroduodenal tuberculosis and Crohn's disease. Patients with chronic pancreatitis-related GOO had poor response to dilatation, with two patients (50%) requiring surgery and the remaining two with recurrence of symptoms requiring repeat dilatation. None of the other patients with successful treatment had recurrence of symptoms. Complication in the form of perforation was noted in two patients (8%).
Endoscopic balloon dilatation is an effective, safe, and minimally invasive treatment modality for benign gastric outlet obstruction.
良性胃出口梗阻(GOO)会导致相当大的发病率,传统的治疗方法是手术。内镜球囊扩张是治疗 GOO 的一种微创治疗方法,但主要是在因消化性溃疡病引起的 GOO 患者中使用。我们报告了我们在各种病因的良性 GOO 中使用内镜球囊扩张的经验。
在 4 年多的时间里,我们用经内镜控制的径向扩张(CRE)球囊扩张器对 25 例良性 GOO 患者进行了内镜球囊扩张治疗。每 2 周重复扩张,终点为扩张至 15mm 或需要手术。存在幽门螺杆菌时,予以根除。
良性 GOO 的病因是消化性溃疡(11)、腐蚀性摄入(7)、慢性胰腺炎(4,其中 1 例为沟槽胰腺炎)、肺结核(2)和克罗恩病(1)。内镜球囊扩张在 21/25(84%)患者中成功。患者需要进行 1 至 6 次内镜扩张(平均 2.2±1.2 次)。腐蚀性摄入引起的 GOO 需要更多的扩张治疗(3.83±0.75 次),而消化性溃疡引起的 GOO 则需要更少的扩张治疗(2.1±0.56 次;p<0.05)。球囊扩张对胃十二指肠结核和克罗恩病引起的 GOO 也有效。慢性胰腺炎相关 GOO 的患者对扩张反应不佳,2 名患者(50%)需要手术,其余 2 名患者因症状复发需要再次扩张。其他成功治疗的患者均无症状复发。有 2 名患者(8%)出现穿孔并发症。
内镜球囊扩张是治疗良性胃出口梗阻的一种有效、安全、微创的治疗方法。