血管紧张素转换酶基因多态性与中国汉族慢性心力衰竭患者的相关性

Association of the angiotensin-converting enzyme gene polymorphism with chronic heart failure in Chinese Han patients.

作者信息

Huang Wenyan, Xie Changqing, Zhou Hongyan, Yang Tianlun, Sun Ming

机构信息

Department of Cardiology, Xiang Ya Hospital, Central South University, Changsha, Hunan, PR China.

出版信息

Eur J Heart Fail. 2004 Jan;6(1):23-7. doi: 10.1016/j.ejheart.2003.09.004.

DOI:10.1016/j.ejheart.2003.09.004

PMID:15012915

Abstract

BACKGROUND

An insertion/deletion (I/D) polymorphism is present in the 16th intron of the angiotensin-converting enzyme (ACE) gene and is associated with serum and tissue ACE level. Some studies have shown that the DD genotype is associated with some cardiovascular diseases; while ACE polymorphism's effect on chronic heart failure (CHF) remains uncertain.

AIM

To investigate the association of the ACE gene I/D polymorphism with CHF in the Chinese Han population.

METHODS

The genotype was determined by polymerase chain reaction in 102 normal controls and in 79 patients with CHF. Plasma angiotensin (Ang) levels were assessed by radio-immunity assay. Left ventricular end-diastolic diameters (LVDD) and left ventricular ejection fractions were assessed by echocardiography.

RESULTS

The ACE gene polymorphism distribution was similar in patients and control subjects. However, ACE gene DD polymorphism was associated with a more severe condition, greater LVDD [mm: DD: 71+/-7, ID: 62+/-5, II: 60+/-5, P<0.001 DD vs. ID, P<0.001 DD vs. II] and higher plasma Ang II level [pg/ml DD: 92+/-19, ID: 79+/-21, II: 65+/-17 P<0.05 DD vs. ID, P<0.001 DD vs. II].

CONCLUSION

In Chinese Han patients with CHF, ACE gene DD polymorphism might be a marker of a more severe condition, and a higher level of activation of the renin-angiotensin system.

摘要

背景

血管紧张素转换酶（ACE）基因第16内含子存在插入/缺失（I/D）多态性，且与血清及组织ACE水平相关。一些研究表明，DD基因型与某些心血管疾病相关；而ACE多态性对慢性心力衰竭（CHF）的影响仍不确定。

目的

研究ACE基因I/D多态性与中国汉族人群CHF的相关性。

方法

采用聚合酶链反应检测102例正常对照者和79例CHF患者的基因型。采用放射免疫分析法评估血浆血管紧张素（Ang）水平。通过超声心动图评估左心室舒张末期内径（LVDD）和左心室射血分数。

结果

患者和对照者的ACE基因多态性分布相似。然而，ACE基因DD多态性与病情更严重、更大的LVDD相关[单位：mm：DD：71±7，ID：62±5，II：60±5，DD与ID相比P<0.001，DD与II相比P<0.001]以及更高的血浆Ang II水平相关[单位：pg/ml：DD：92±19，ID：79±21，II：65±17，DD与ID相比P<0.05，DD与II相比P<0.001]。