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Effects of GRK5 and ADRB1 polymorphisms influence on systolic heart failure.GRK5和ADRB1基因多态性对收缩性心力衰竭的影响。
J Transl Med. 2015 Feb 1;13:44. doi: 10.1186/s12967-015-0402-7.
2
Variants in miRNA regulating cardiac growth are not a common cause of hypertrophic cardiomyopathy.调控心脏生长的微小RNA变异并非肥厚型心肌病的常见病因。
Cardiology. 2015;130(3):137-42. doi: 10.1159/000369247. Epub 2015 Jan 24.
3
Chemistry, physiology, and pharmacology of β-adrenergic mechanisms in the heart. Why are β-blocker antiarrhythmics superior?心脏中β-肾上腺素能机制的化学、生理学及药理学。为何β受体阻滞剂类抗心律失常药更具优势？
Curr Pharm Des. 2015;21(8):1030-41. doi: 10.2174/1381612820666141029111240.
4
Vascular endothelial growth factor-B in physiology and disease.血管内皮生长因子-B 在生理和疾病中的作用。
Physiol Rev. 2014 Jul;94(3):779-94. doi: 10.1152/physrev.00028.2013.
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Genetic predisposition to left ventricular dysfunction: a multigenic and multi-analytical approach.左心室功能障碍的遗传易感性：一种多基因和多分析方法。
Gene. 2014 Aug 10;546(2):309-17. doi: 10.1016/j.gene.2014.05.060. Epub 2014 May 27.
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Angiotensin-converting enzyme genetic polymorphism: its impact on cardiac remodeling.血管紧张素转换酶基因多态性：对心脏重构的影响。
Arq Bras Cardiol. 2014 Jan;102(1):70-9. doi: 10.5935/abc.20130229. Epub 2013 Nov 26.
7
No association of G-protein-coupled receptor kinase 5 or β-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort.在一个大型澳大利亚队列中，G 蛋白偶联受体激酶 5 或 β-肾上腺素能受体多态性与 Takotsubo 心肌病之间没有关联。
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Association of tumor necrosis factor-α gene G-308A polymorphism with dilated cardiomyopathy: a meta-analysis.肿瘤坏死因子-α基因 G-308A 多态性与扩张型心肌病的关系：一项荟萃分析。
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Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass.常见变异邻近 micro-RNA 22 与左心室质量增加相关。
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与心力衰竭相关的基因多态性：文献综述。

Genetic polymorphisms associated with heart failure: A literature review.

作者信息

Guo Mengqi, Guo Guanlun, Ji Xiaoping

机构信息

Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China.

Hubei Key Laboratory of Advanced Technology of Automotive Components, School of Automotive Engineering, Wuhan University of Technology, Wuhan, China.

出版信息

J Int Med Res. 2016 Feb;44(1):15-29. doi: 10.1177/0300060515604755. Epub 2016 Jan 14.

DOI:10.1177/0300060515604755
PMID:26769713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5536573/
Abstract

OBJECTIVE

To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure.

METHODS

Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015.

RESULTS

Eighty-two articles covering 29 genes and 39 polymorphisms were identified.

CONCLUSION

Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure.

摘要

目的

综述已报道的基因变异与心力衰竭的风险、治疗反应及预后之间可能存在的关联。

方法

系统检索电子数据库（PubMed、Web of Science和中国知网），查找1995年1月至2015年2月发表的相关论文。

结果

共识别出82篇涵盖29个基因和39个多态性的文章。

结论

心力衰竭的基因关联研究一直存在高度争议。可能存在几种基因变异的相互作用或协同作用，共同导致心力衰竭的最终病理表型。