与心力衰竭相关的基因多态性：文献综述。
Genetic polymorphisms associated with heart failure: A literature review.
作者信息
Guo Mengqi, Guo Guanlun, Ji Xiaoping
机构信息
Key Laboratory of Cardiovascular Remodeling and Function Research, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China.
Hubei Key Laboratory of Advanced Technology of Automotive Components, School of Automotive Engineering, Wuhan University of Technology, Wuhan, China.
出版信息
J Int Med Res. 2016 Feb;44(1):15-29. doi: 10.1177/0300060515604755. Epub 2016 Jan 14.
Abstract
OBJECTIVE
To review possible associations reported between genetic variants and the risk, therapeutic response and prognosis of heart failure.
METHODS
Electronic databases (PubMed, Web of Science and CNKI) were systematically searched for relevant papers, published between January 1995 and February 2015.
RESULTS
Eighty-two articles covering 29 genes and 39 polymorphisms were identified.
CONCLUSION
Genetic association studies of heart failure have been highly controversial. There may be interaction or synergism of several genetic variants that together result in the ultimate pathological phenotype for heart failure.
摘要
目的
综述已报道的基因变异与心力衰竭的风险、治疗反应及预后之间可能存在的关联。
方法
系统检索电子数据库（PubMed、Web of Science和中国知网），查找1995年1月至2015年2月发表的相关论文。
结果
共识别出82篇涵盖29个基因和39个多态性的文章。
结论
心力衰竭的基因关联研究一直存在高度争议。可能存在几种基因变异的相互作用或协同作用，共同导致心力衰竭的最终病理表型。
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