作为血管内皮生长因子受体激酶插入域受体（VEGF-receptor KDR）抑制剂的3,7-二芳基咪唑并吡啶的设计与合成
Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.
作者信息
Wu Zhicai, Fraley Mark E, Bilodeau Mark T, Kaufman Mildred L, Tasber Edward S, Balitza Adrienne E, Hartman George D, Coll Kathleen E, Rickert Keith, Shipman Jennifer, Shi Bin, Sepp-Lorenzino Laura, Thomas Kenneth A
机构信息
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA.
出版信息
Bioorg Med Chem Lett. 2004 Feb 23;14(4):909-12. doi: 10.1016/j.bmcl.2003.12.007.
PMID:15012992
Abstract
3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.
摘要
3,7-二芳基取代的咪唑并吡啶被设计开发为一类新型的KDR激酶抑制剂。合成了多种咪唑并吡啶，并鉴定出具有良好水溶性的KDR激酶活性强效抑制剂。
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