利用正电子发射断层扫描（PET）和[11C]多塞平对人脑中组胺H(1)受体进行定量测量。

Quantitative measurement of histamine H(1) receptors in human brains by PET and [11C]doxepin.

作者信息

Mochizuki Hideki, Kimura Yuichi, Ishii Kenji, Oda Keiichi, Sasaki Toru, Tashiro Manabu, Yanai Kazuhiko, Ishiwata Kiichi

机构信息

Department of Phamacology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Nucl Med Biol. 2004 Feb;31(2):165-71. doi: 10.1016/j.nucmedbio.2003.08.010.

DOI:10.1016/j.nucmedbio.2003.08.010

PMID:15013481

Abstract

The aim of this study is to establish a method for quantitative measurement of histamine H(1) receptor (H1R) in human brain by PET and [(11)C]doxepin ([(11)C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [(11)C]DOX and PET can be evaluated with a two-compartment model.

摘要

本研究的目的是建立一种通过正电子发射断层扫描（PET）和[¹¹C]多塞平（[¹¹C]DOX）对人脑组胺H(1)受体（H1R）进行定量测量的方法。用二室模型估计的参数对于参数估计的初始值是稳定的，但三室模型的参数不稳定。这一发现表明，用[¹¹C]DOX和PET测量的H1R可用二室模型进行评估。