抗精神病药物对老年患者的影响：疗效、剂量与依从性
Impact of Antipsychotics on Geriatric Patients: Efficacy, Dosing, and Compliance.
作者信息
Maguire Gerald A.
机构信息
Department of Psychiatry, University of California, Irvine.
出版信息
Prim Care Companion J Clin Psychiatry. 2000 Oct;2(5):165-172. doi: 10.4088/pcc.v02n0503.
People today are living longer. Old age is the number one risk factor for dementia, which is often associated with behavioral disturbances and psychosis as well as cognitive and memory impairment. Elderly persons with dementia-particularly those who are agitated or aggressive-are often placed in nursing homes and consequently treated with antipsychotic medications. Most of the studies of antipsychotic efficacy and safety have been conducted in young schizophrenic patients, but there are differences in dosing schedules, efficacy, and compliance when these drugs are used in elderly patients with dementia and psychosis. A review of both nonpharmacologic and pharmacologic treatment is herewith presented for the treatment of elderly dementia patients, especially those living in long-term care facilities.
如今人们的寿命越来越长。老年是痴呆症的首要风险因素，痴呆症通常与行为障碍、精神病以及认知和记忆障碍有关。患有痴呆症的老年人——尤其是那些烦躁不安或有攻击性的人——往往会被安置在养老院，因此会接受抗精神病药物治疗。大多数关于抗精神病药物疗效和安全性的研究都是在年轻的精神分裂症患者中进行的，但当这些药物用于患有痴呆症和精神病的老年患者时，在给药方案、疗效和依从性方面存在差异。本文对老年痴呆症患者，尤其是长期护理机构中的患者的非药物和药物治疗进行综述。
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