黄芪对自发性高血压大鼠压力反射敏感性的影响
[Effect of Astragalus membranaceus on baroreflex sensitivity in spontaneously hypertensive rats].
作者信息
Chen Zhi-kui, Hu Shen-jiang, Zhen Xia, Wang Guo-bing, Sun Jian, Xia Qiang, Sheng Yue-liang
机构信息
Department of Cardiovascular, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, Zhejiang, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2003 Feb;28(2):155-8.
OBJECTIVE
To observe the chronicity decompression effect of Astragalus Membranaceus(AM) and evaluate the effect on baroreflex sensitivity (BRS).
METHOD
Nineteen spontaneously hypertensive rats(SHR) were randomly divided into four groups. The AM groups were intraperitoneally administered with AM parenteral solution 0.9 mL, 1.2 mL and 1.8 mL respectively and the control group was not given AM for eight weeks. Then the change of blood pressure was observed successivly. After eight weeks, BRS were also determined. At last, the difference of blood pressure and BRS among the groups were compared.
RESULT
Blood pressure in the control group became higher and higher frome the third week to the eighth week, but the other SHR admistered with AM showed no changein blood pressure level. We also found that the BRS in AM group was higher than that in the control group(P < 0.01).
CONCLUSION
AM can promote the BRS in SHR.
目的
观察黄芪的慢性减压作用，并评估其对压力反射敏感性（BRS）的影响。
方法
将19只自发性高血压大鼠（SHR）随机分为四组。黄芪组分别腹腔注射0.9 mL、1.2 mL和1.8 mL黄芪注射液，对照组连续8周不给予黄芪。随后连续观察血压变化。8周后，测定压力反射敏感性。最后，比较各组血压和压力反射敏感性的差异。
结果
从第3周开始至第8周，对照组血压持续升高，而其他给予黄芪的自发性高血压大鼠血压水平无变化。我们还发现，黄芪组的压力反射敏感性高于对照组（P<0.01）。
结论
黄芪可提高自发性高血压大鼠的压力反射敏感性。
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