肺血管平滑肌细胞增殖中的钙通道和瞬时受体电位通道
Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.
作者信息
Landsberg Judd W, Yuan Jason X-J
机构信息
Department of Medicine, School of Medicine, University of California, San Diego, California 92103, USA.
出版信息
News Physiol Sci. 2004 Apr;19:44-50. doi: 10.1152/nips.01457.2003.
PMID:15016901
Abstract
Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.
摘要
钙离子（Ca²⁺）是肺血管收缩的主要触发因素，也是肺血管平滑肌细胞增殖的刺激因素。瞬时受体电位阳离子通道参与调节细胞内钙离子（Ca²⁺），进而影响血管收缩性和细胞增殖。编码这些通道的基因上调与肺动脉高压的发生发展有关。
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