人视网膜基底膜的剥脱：超微结构效应

Peeling of the basal membrane in the human retina: ultrastructural effects.

作者信息

Wolf Sebastian, Schnurbusch Ute, Wiedemann Peter, Grosche Jens, Reichenbach Andreas, Wolburg Hartwig

机构信息

Department of Ophthalmology and Eye Clinic, Leipzig University, Leipzig, Germany.

出版信息

Ophthalmology. 2004 Feb;111(2):238-43. doi: 10.1016/j.ophtha.2003.05.022.

DOI:10.1016/j.ophtha.2003.05.022

PMID:15019369

Abstract

PURPOSE

To study the effects of internal limiting membrane (ILM) peeling, usually performed in cases of macular hole formation, on the structural integrity of the human retina.

DESIGN

Experimental study.

MATERIAL

Two human donor eyes.

METHODS

A human donor retina was subjected to ILM peeling shortly after enucleation, fixed, and studied by electron microscopy.

MAIN OUTCOME MEASURES

Electron microscopic findings.

RESULTS

Within the peeled area, and even at its margins, a substantial number of Müller (glial) cell endfeet and vitreal Müller cell processes was severely damaged. However, many glial cells remained intact, and the cell bodies of the injured cells showed no signs of destruction.

CONCLUSIONS

We have shown that ILM peeling results in minor, but demonstrable, damage of the adjacent retina. Clinical studies are required to demonstrate unequivocally that ILM peeling does not induce functional deficits rather than improvement of visual function.

摘要