ISWI在转录、染色体组织和DNA复制中的多种作用。
Multiple roles for ISWI in transcription, chromosome organization and DNA replication.
作者信息
Corona Davide F V, Tamkun John W
机构信息
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 350 Sinsheimer Labs, Santa Cruz, CA 95064, USA.
出版信息
Biochim Biophys Acta. 2004 Mar 15;1677(1-3):113-9. doi: 10.1016/j.bbaexp.2003.09.018.
ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.
ISWI作为多种染色质重塑复合物的ATP酶亚基发挥作用。这些复合物利用ATP水解产生的能量使核小体滑动并增加染色质的流动性，从而调节转录因子和其他调节蛋白与DNA的结合。在此，我们讨论了在理解ISWI生物学功能方面的最新进展，重点关注其在转录、染色体组织和DNA复制中的作用。
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