Waits Paula S, Purcell Wendy M, Fulford Allison J, McLeod Julie D
Faculty of Applied Sciences, Centre for Research in Biomedicine, University of the West of England, Coldharbour Lane, Frenchay, Bristol, BS16 1QY, UK.
J Neuroimmunol. 2004 Apr;149(1-2):110-20. doi: 10.1016/j.jneuroim.2003.12.018.
Although nociceptin/orphanin FQ (N/OFQ) and its receptor (ORL-1) are widely distributed throughout the immune system, its role has yet to be elucidated. This study shows that N/OFQ (10(-14)-10(-12) M) modulates T cell activation by up-regulating activation marker expression, e.g. CD28, leading to enhanced proliferation and modulation of TNFalpha secretion. However, on re-stimulated T cells N/OFQ causes inhibition of proliferation, which could be linked with N/OFQ up-regulating CTLA-4 expression. We have also shown that some of these effects are partly prostaglandin-dependent and that N/OFQ induces prostaglandin synthesis. This report suggests that N/OFQ could exert a key modulatory role in human T cell functions.
尽管痛敏肽/孤啡肽（N/OFQ）及其受体（ORL-1）广泛分布于整个免疫系统，但其作用尚未阐明。本研究表明，N/OFQ（10^(-14)-10^(-12) M）通过上调激活标志物如CD28的表达来调节T细胞活化，从而导致增殖增强和肿瘤坏死因子α分泌的调节。然而，在再次刺激的T细胞上，N/OFQ会抑制增殖，这可能与N/OFQ上调细胞毒性T淋巴细胞相关抗原4（CTLA-4）的表达有关。我们还表明，其中一些作用部分依赖于前列腺素，并且N/OFQ可诱导前列腺素合成。本报告表明，N/OFQ可能在人类T细胞功能中发挥关键的调节作用。
