Haraoka S, Saito D, Ueda M, Ogino Y, Yoshida H, Kusuhara S, Yoshioka N, Kawasaki T
Acta Med Okayama. 1978 Jun;32(2):97-107.
The correlation between the systolic time interval and abnormal contraction in ischemic myocardium was studied in anesthetized open-chest dogs. A strain-gauge was sutured on the surface of the left ventricular wall perfused by the left anterior descending coronary artery (LAD) for measuring segment-length. The left ventricular stroke volume decreased progressively after occlusion of LAD. The left ventricular ejection time (LVET) was progressively shortened in close correlation with the elongation of segment-length at the onset of isometric relaxation in 20 seconds after LAD occlusion when early systolic myocardial contraction and isometric contraction time (ICT) were not affected. ICT was gradually prolonged and closely related with the lengthening of the early systolic segment-length, while LVET recovered toward the control level in spite of further decrease in stroke volume. A close relationship was observed between ICT/LVET and stroke volume (gamma = 0.76, P less than 0.01). The results suggested the possibility that LVET was normalized even when the left ventricular function was impaired, and ICT/LVET ratio was the most sensitive index of LV dysfunction.
在麻醉开胸犬身上研究了收缩期时间间期与缺血心肌异常收缩之间的相关性。将应变片缝合在由左前降支冠状动脉（LAD）灌注的左心室壁表面，用于测量节段长度。LAD闭塞后左心室每搏量逐渐下降。LAD闭塞后20秒内，等容舒张开始时节段长度延长，左心室射血时间（LVET）与之密切相关且逐渐缩短，此时收缩早期心肌收缩和等容收缩时间（ICT）未受影响。ICT逐渐延长并与收缩早期节段长度的延长密切相关，而尽管每搏量进一步下降，LVET仍恢复至对照水平。观察到ICT/LVET与每搏量之间存在密切关系（γ = 0.76，P < 0.01）。结果提示，即使左心室功能受损，LVET仍有可能恢复正常，且ICT/LVET比值是左心室功能障碍最敏感的指标。
