Girard Melissa, Israël-Assayag Evelyne, Cormier Yvon
Institute of Cardiology and Pneumology Research Centre, Laval University, Laval Hospital, Quebec, Canada.
Curr Opin Allergy Clin Immunol. 2004 Apr;4(2):93-8. doi: 10.1097/00130832-200404000-00004.
Hypersensitivity pneumonitis is a group of immunologically mediated diseases caused by an abnormal response to a wide variety of inhaled antigens. Its pathogenesis is complex and involves many immunological concepts. This review discusses recent advances in our understanding of the pathogenesis of hypersensitivity pneumonitis.
Over the last 3 years, several studies on the pathogenesis of hypersensitivity pneumonitis have been published. New antigens have been identified. We now have a better understanding of the role of inflammatory cells and mediators, and promoting and protective factors have been suggested.
Most of the mechanisms involved in the pathogenesis of hypersensitivity pneumonitis remain incompletely understood. Current and future findings will not only help our understanding of the disease and its prevention, but also improve its treatment.
过敏性肺炎是一组由对多种吸入性抗原的异常反应引起的免疫介导性疾病。其发病机制复杂，涉及许多免疫学概念。本综述讨论了我们对过敏性肺炎发病机制理解的最新进展。
在过去3年里，发表了几项关于过敏性肺炎发病机制的研究。已鉴定出新的抗原。我们现在对炎症细胞和介质的作用有了更好的理解，并提出了促进因素和保护因素。
过敏性肺炎发病机制中涉及的大多数机制仍未完全了解。当前和未来的研究结果不仅将有助于我们对该疾病及其预防的理解，还将改善其治疗。
