Richard Jean-Christophe, Chen Delphine L, Ferkol Tom, Schuster Daniel P
Departments of Internal Medicine, Pediatrics, and Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
Pediatr Pulmonol. 2004 Apr;37(4):286-96. doi: 10.1002/ppul.20024.
Molecular imaging is a rapidly developing multidisciplinary field that combines advances in contrast agent development, instrumentation, and molecular/cell biology to follow cellular and sub-cellular events in intact organisms. Platforms for molecular imaging include radionuclide-based methods, optical methods, and magnetic resonance. To date, molecular imaging studies of the lungs have been used to monitor the effectiveness of gene transfer, neutrophilic inflammation, and cell trafficking. Eventually, the goal will be to translate these new techniques to clinical settings such as cystic fibrosis.
分子成像技术是一个快速发展的多学科领域，它结合了造影剂开发、仪器设备以及分子/细胞生物学等方面的进展，用于追踪完整生物体中的细胞和亚细胞事件。分子成像平台包括基于放射性核素的方法、光学方法和磁共振方法。迄今为止，肺部的分子成像研究已被用于监测基因转移、嗜中性粒细胞炎症和细胞迁移的效果。最终目标是将这些新技术应用于临床环境，如囊性纤维化。
