Molho Eric S
Albany Medical College, Department of Neurology, Albany, New York, USA.
Mov Disord. 2004 Mar;19(3):341-4. doi: 10.1002/mds.10665.
An 85-year-old man presented with 3 years of a progressive akinetic rigid syndrome with ataxia, falls, levodopa unresponsiveness, and autonomic dysfunction. Early in the course of illness, cranial magnetic resonance imaging (MRI) was thought to show pontine enlargement but later was reinterpreted by experts as normal. Two subsequent cranial MRIs were believed to show only mild atrophy. An initial clinical diagnosis of multiple system atrophy was made. The patient died 4 years after the onset of symptoms. Pathological examination revealed diffuse infiltration of multiple brain regions with cells of astrocytic and microglial origin consistent with a diagnosis of gliomatosis cerebri.
一名85岁男性，出现进行性运动不能-强直综合征3年，伴有共济失调、跌倒、左旋多巴无反应及自主神经功能障碍。病程早期，头颅磁共振成像（MRI）被认为显示脑桥增大，但后来专家重新解读为正常。随后的两次头颅MRI被认为仅显示轻度萎缩。最初临床诊断为多系统萎缩。患者在症状出现4年后死亡。病理检查显示多个脑区有弥漫性浸润，细胞起源于星形胶质细胞和小胶质细胞，符合大脑胶质瘤病的诊断。
