在肿瘤治疗的预激活条件下形成的部花青540的光氧化产物。
Photooxidation products of merocyanine 540 formed under preactivation conditions for tumor therapy.
作者信息
Franck B, Schneider U
机构信息
Organisch-Chemisches Institut, Universität Münster, Germany.
出版信息
Photochem Photobiol. 1992 Aug;56(2):271-6. doi: 10.1111/j.1751-1097.1992.tb02157.x.
In order to gain insight into the preactivation of merocyanine 540 (MC540) 1 for the photodynamic therapy (Gulliya et al., 1990a, Photochem. Photobiol. 52, 831-838) its photo-oxidation was investigated. After irradiation of MC540 1 on a preparative scale three main photodegradation products were isolated with 16-20% yields. They turned out to be derivatives of benzoxazole, thiouracil and thiohydantoin with the structures 4, 5 and 6, respectively. It may be possible that they contribute to the cytostatic and antiviral activity of preactivated MC540 1.
为深入了解用于光动力疗法的部花青540（MC540）1的预激活情况（古利亚等人，1990年a，《光化学与光生物学》52卷，831 - 838页），对其光氧化过程进行了研究。在制备规模上对MC540 1进行辐照后，分离出了三种主要的光降解产物，产率为16% - 20%。结果表明它们分别是苯并恶唑、硫脲嘧啶和硫代乙内酰脲的衍生物，结构分别为4、5和6。它们有可能对预激活的MC540 1的细胞抑制和抗病毒活性有贡献。
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