Hanada Masahito, Feng Jianhua, Hemmings Brian A
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH-4058, Switzerland.
Biochim Biophys Acta. 2004 Mar 11;1697(1-2):3-16. doi: 10.1016/j.bbapap.2003.11.009.
Protein phosphorylation and dephosphorylation play a major role in intracellular signal transduction activated by extracellular stimuli. Protein kinase B (PKB/Akt) is a central player in the signal transduction pathways activated in response to growth factors or insulin and is thought to contribute to several cellular functions including nutrient metabolism, cell growth and apoptosis. Recently, several significant publications have described novel mechanisms used to regulate PKB. Since the alteration of PKB activity is associated with several human diseases, including cancer and diabetes, understanding PKB regulation is an important task if we are to develop successful therapeutics.
蛋白质磷酸化和去磷酸化在由细胞外刺激激活的细胞内信号转导中起主要作用。蛋白激酶B（PKB/Akt）是在响应生长因子或胰岛素时激活的信号转导途径中的核心参与者，并且被认为有助于多种细胞功能，包括营养物质代谢、细胞生长和细胞凋亡。最近，几篇重要的出版物描述了用于调节PKB的新机制。由于PKB活性的改变与包括癌症和糖尿病在内的几种人类疾病相关，如果我们要开发成功的治疗方法，了解PKB的调节是一项重要任务。
