Benz G W, Ernst J V
Am J Vet Res. 1978 Jul;39(7):1107-8.
Anthelmintic activity of albendazole against adult Dictyocaulus viviparus was evaluated in a controlled experiment. Calves were raised nematode-free to approximately 8 weeks of age and were each given 4,000 infective 3rd-stage larvae. Twenty calves with patent parasitisms were allotted to 2 groups of 10 calves each. Calves in group 1 were used as nonmedicated controls, and calves in group 2 were given albendazole in paste formulation at the dosage concentration of 7.5 mg/kg of body weight on the 30th day after administration of infective larvae. At necropsy, nonmedicated control calves had a total of 308 adult D viviparus, whereas the albendazole-treated calves had 11, for an average efficacy of 96.4%. These reductions were statistically highly significant (P less than 0.01). At necropsy, none of the treated calves was passing 1st-stage C viviparus larvae in their feces, whereas control calves were passing an average of 46 larvae/10 g of feces.
在一项对照实验中评估了阿苯达唑对成年胎生网尾线虫的驱虫活性。将犊牛饲养至约8周龄且无线虫感染，每头犊牛接种4000条感染性三期幼虫。将20头有明显寄生虫感染的犊牛分为两组，每组10头。第1组犊牛作为未用药对照组，第2组犊牛在接种感染性幼虫后第30天，以7.5毫克/千克体重的剂量浓度给予阿苯达唑膏剂。尸检时，未用药的对照犊牛共有308条成年胎生网尾线虫，而用阿苯达唑治疗的犊牛有11条，平均疗效为96.4%。这些减少在统计学上具有高度显著性（P小于0.01）。尸检时，接受治疗的犊牛粪便中均未排出一期胎生网尾线虫幼虫，而对照犊牛粪便中平均每10克排出46条幼虫。
