Rosselli A, Landini G, Castagnoli A, Vannucchi L, Mugnaini C, Calacoci S, Regoli G, Francesconi A, Turchi A, Agostino I
U.O. Medicina interna II, Ospedale S.M. Annunziata, USL 10/H, Firenze.
Recenti Prog Med. 1992 Feb;83(2):85-8.
Aim of the study is the evaluation of therapeutic effectiveness of nimodipine in acute focal cerebral ischaemia. Thirty patients affected by minor ischaemic stroke divided in two randomized groups have been studied consecutively: all the patients were treated with standard therapy, nimodipine was delivered in addition only to the patients of the first group. Both clinical evaluation using Mathew scale, modified by Gelmers, and flowmetric evaluation with SPECT were performed at different times. The results haven't shown any significant statistical difference in the effectiveness of the therapy between the two groups even if a positive clinical trend was evidenced in the group treated with nimodipine. The flowmetric study has shown the poor homogeneity of the groups from a physiopathological point of view not-with-standing the two groups were similar for the clinical severity, sex, age and vascular risk factors. We conclude that is advisable to carry out further trials in which the comparison study groups are more numerous and balanced also from a physiopathological point of view.
本研究的目的是评估尼莫地平在急性局灶性脑缺血中的治疗效果。连续研究了30例轻度缺血性中风患者，将其分为两个随机组：所有患者均接受标准治疗，仅第一组患者额外给予尼莫地平。分别在不同时间使用经格尔默斯修改的马修量表进行临床评估，以及用单光子发射计算机断层扫描（SPECT）进行血流测定评估。结果显示，两组治疗效果在统计学上无显著差异，尽管在接受尼莫地平治疗的组中显示出积极的临床趋势。血流测定研究表明，从生理病理学角度来看，两组的同质性较差，尽管两组在临床严重程度、性别、年龄和血管危险因素方面相似。我们得出结论，建议进行进一步试验，在这些试验中，比较研究组在生理病理学角度上数量更多且更均衡。
