Shohat Izhar, Berkowicz Miriam, Dori Shai, Horowitz Zeev, Wolf Michael, Taicher Shlomo, Talmi Yoav P
Department of Oral and Maxillofacial Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Mar;97(3):328-31. doi: 10.1016/j.tripleo.2003.10.011.
We sought to review the records of patients seen at the Chaim Sheba Medical Center (Tel Hashomer, Israel) during a 10-year period with respect to the presenting features, management, and outcome of extranodal non-Hodgkin's lymphoma (NHL) of the sinonasal region.
Eight patients were diagnosed with NHL of the paranasal sinuses from 1993 to 2003. The data were reviewed, and we noted the patient's age, sex, the presenting signs and symptoms, staging, histology, treatment, and outcome of NHL.
The mean age was 61.75 years (range, 24-83 years), with a 1:1 male-to-female ratio. All cases involved the paranasal sinuses, and the most common symptom was nasal obstruction (6 patients). All the patients had large B-cell lymphoma, and all were treated with combined chemotherapy and radiation. Three patients died from the disease, 3 were free of disease after 12 to 36 months of follow-up, and 1 had a recurrence after 60 months.
NHLs of the paranasal sinuses are uncommon. Early diagnosis and combined treatment are essential for achieving an optimal outcome.
我们试图回顾在10年期间于以色列特拉维夫哈绍默的海姆·谢巴医疗中心就诊的患者记录，内容涉及鼻窦结外非霍奇金淋巴瘤（NHL）的临床表现、治疗及预后。
1993年至2003年期间，8例患者被诊断为鼻窦NHL。对数据进行回顾，我们记录了患者的年龄、性别、临床表现、分期、组织学、NHL的治疗及预后情况。
平均年龄为61.75岁（范围24 - 83岁），男女比例为1:1。所有病例均累及鼻窦，最常见症状为鼻塞（6例患者）。所有患者均为大B细胞淋巴瘤，均接受了联合化疗及放疗。3例患者死于该疾病，3例在随访12至36个月后无病生存，1例在60个月后复发。
鼻窦NHL并不常见。早期诊断及联合治疗对于取得最佳预后至关重要。
