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[术后细菌性骨炎的诊断与随访管理]

[Diagnosis and follow-up management of postoperative bacterial osteitis].

作者信息

Flückiger U, Zimmerli W

机构信息

Klinik für Infektiologie, Kantonsspital, Universitätskliniken Basel, Switzerland.

出版信息

Orthopade. 2004 Apr;33(4):416-23. doi: 10.1007/s00132-003-0606-z.

Abstract

Osteomyelitis is a term used to describe bone infection. As a complication, it can occur after open bone fracture and is associated with the implantation of foreign material. Acute disease after surgery starts after about 7 days to 4 weeks, and is characterized by a suppurative infection. Chronic infection sometimes manifests even years after surgery with a purulent sinus tract. Diagnosis is based on clinical signs, microbiological culture, histological evidence of the presence of granulocytes, and on radiological signs of osteomyelitis. However, it is sometimes difficult to distinguish between merely soft tissue involvement and osteomyelitis, especially in the presence of implanted material. Management includes a thoroughly surgical débridement and antibiotic treatment. Though frequently used, bacterial cultures of swabs of superficial wounds or fistulas are often misleading, whereas needle biopsy or surgical sampling with at least three tissue samples provides more reliable information. Because of the prolonged antibiotic treatment, it is mandatory for a successful outcome to culture the microorganism in order to determine antibiotic susceptibility. In addition to conventional radiological approaches, magnetic resonance imaging has become useful for the diagnosis of osteomyelitis. Despite significant progress in antibiotic therapy and orthopedic surgery, osteomyelitis remains difficult to treat and often relapses, even after years.

摘要

骨髓炎是一个用于描述骨感染的术语。作为一种并发症,它可发生于开放性骨折后,并与异物植入有关。术后急性疾病在约7天至4周后开始,其特征为化脓性感染。慢性感染有时甚至在术后数年才表现为脓性窦道。诊断基于临床体征、微生物培养、粒细胞存在的组织学证据以及骨髓炎的影像学征象。然而,有时仅软组织受累与骨髓炎之间难以区分,尤其是在存在植入材料的情况下。治疗包括彻底的手术清创和抗生素治疗。虽然浅表伤口或瘘管拭子的细菌培养经常使用,但往往具有误导性,而针吸活检或至少取三个组织样本的手术采样可提供更可靠的信息。由于抗生素治疗时间较长,为获得成功的治疗结果,培养微生物以确定抗生素敏感性是必不可少的。除了传统的放射学方法外,磁共振成像已对骨髓炎的诊断很有用。尽管抗生素治疗和矫形外科取得了显著进展,但骨髓炎仍然难以治疗,甚至数年之后也常复发。

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