Gudmundsson F F, Heltne J K
Surgical Research Laboratory, Institute of Surgical Sciences, University of Bergen, Norway.
Acta Anaesthesiol Scand. 2004 Apr;48(4):463-8. doi: 10.1111/j.0001-5172.2004.0354.x.
Increased intra-abdominal pressure (IAP) elevates thoracic pressure and airway pressures and reduces lung compliance in humans and laboratory animals. We studied respiratory alterations and arterial blood gas changes in pigs with IAP maintained at 20 mmHg or 30 mmHg for 3 h.
Domestic pigs of both sexes weighing 30.0 +/- 5.1 kg (mean +/- SD) (n = 21) were divided into three groups. The animals were anesthetized and kept at 20 mmHg IAP (n = 7) or 30 mmHg IAP (n = 7) for 3 h. The third group (n = 7) served as control without an elevated IAP. We recorded respiratory alterations and changes in acid-based parameters at baseline and after 90 min and 180 min of increased IAP.
No significant hypoxia or hypercarbia was found in animals with an IAP of 20 mmHg IAP. At an IAP of 30 mmHg, pO2 decreased to an average 19.6 kPa and pCO2 increased to about 6 kPa, and the animals were slightly acidotic. Airway pressure increased significantly and lung compliance decreased in both groups of elevated IAP.
In our porcine model, an IAP of 20 mmHg or higher for 3 h is harmful for the respiratory function of the animals due to deterioration of respiratory parameters, increased airway pressure and decreased lung compliance.
腹内压（IAP）升高会使胸腔压力和气道压力升高，并降低人和实验动物的肺顺应性。我们研究了IAP维持在20 mmHg或30 mmHg 3小时的猪的呼吸改变和动脉血气变化。
将体重30.0±5.1 kg（均值±标准差）的21头雌雄家猪分为三组。动物麻醉后，分别在20 mmHg IAP（n = 7）或30 mmHg IAP（n = 7）下维持3小时。第三组（n = 7）作为对照，IAP未升高。我们记录了基线时以及IAP升高90分钟和180分钟后的呼吸改变和酸碱参数变化。
IAP为20 mmHg的动物未发现明显的低氧血症或高碳酸血症。IAP为30 mmHg时，pO2降至平均19.6 kPa，pCO2升至约6 kPa，动物出现轻度酸中毒。两组IAP升高时气道压力均显著升高，肺顺应性降低。
在我们的猪模型中，IAP在20 mmHg或更高水平持续3小时对动物的呼吸功能有害，原因是呼吸参数恶化、气道压力升高和肺顺应性降低。
