Sharma Rajendra, Yang Yusong, Sharma Abha, Awasthi Sanjay, Awasthi Yogesh C
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77550, USA.
Antioxid Redox Signal. 2004 Apr;6(2):289-300. doi: 10.1089/152308604322899350.
It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that these enzymes can also detoxify lipid peroxidation end products such as 4-hydroxynonenal (4-HNE). In this article, recent studies suggesting that the Alpha class GSTs provide a formidable defense against oxidative stress are critically evaluated and the role of these enzymes in the regulation of oxidative stress-mediated signaling is reviewed. Available evidence from earlier studies together with results of recent studies in our laboratories strongly suggests that lipid peroxidation products, particularly hydroperoxides and 4-HNE, are involved in the mechanisms of stress-mediated signaling and that it can be modulated by the Alpha class GSTs through the regulation of the intracellular concentrations of 4-HNE.
已知谷胱甘肽S-转移酶（GSTs）可通过其不依赖硒的谷胱甘肽过氧化物酶活性来还原脂质氢过氧化物，并且这些酶还能使脂质过氧化终产物如4-羟基壬烯醛（4-HNE）解毒。在本文中，对近期表明α类GSTs能对氧化应激提供强大防御作用的研究进行了批判性评估，并综述了这些酶在氧化应激介导的信号调节中的作用。早期研究的现有证据以及我们实验室近期研究的结果有力地表明，脂质过氧化产物，特别是氢过氧化物和4-HNE，参与了应激介导的信号传导机制，并且α类GSTs可通过调节细胞内4-HNE的浓度对其进行调控。
